Glixx Laboratories Inc
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Glixx Laboratorie
CAS: 1957203-01-8
Chemical Name: YKL-05-124; (S)-3-(4-Acrylamidobenzamido)-N-(2-(dimethylamino)-1-phenylethyl)-6,6-dimethyl-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxamide
Purity: >98% (HPLC)
Novel potent and highly selective covalent CDK7 inhibitor, causing arrest at the G1/S transition and inhibition of E2F-driven gene expression, resulting in no change to RNA polymerase II C-terminal domain phosphorylation
References:
1) https://stke.sciencemag.org/content/13/618/eabb1864
2) https://www.sciencedirect.com/science/article/abs/pii/S2451945619300674
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