Glixx Laboratories Inc
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Glixx Laboratorie
CAS: 1263774-59-9
Chemical Name: JTE-052; 3-[(3S,4R)-3-Methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)- 1,6-diazaspiro[3.4]octan-1-yl]-3-oxopropanenitrile
Cat No: GLXC-12185
For Lab R&D Uses Only
Purity: >98% (HPLC)
Storage: Refrigerator (4 °C)
Novel Janus kinase (JAK) inhibitor, inhibiting the JAK1, JAK2, JAK3, and tyrosine kinase (Tyk)2 enzymes in an adenosine triphosphate (ATP)-competitive manner and also inhibiting cytokine signaling evoked by IL-2, IL-6, IL-23, granulocyte/macrophage colony-stimulating factor, and IFN-α
References:
1) https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c00450
2) https://www.jaad.org/article/S0190-9622(19)33289-X/fulltext
3) https://www.jdsjournal.com/article/S0923-1811(19)30393-7/fulltext
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