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PD-1/PD-L1 inhibitor CH1




Chemical Name: (S)-1-(5-Chloro-4-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)-2-((4-(trifluoromethoxy)benzyl)oxy)benzyl)piperidine-2-carboxylic acid


GLXC-24268For Lab R&D Uses Only
        Cat No: GLXC-24268


Purity:               >98% (HPLC)

Storage:             Refrigerator (4 °C)



Product Description:

Novel inhibitor of PD-1/PD-L1 (IC50 value of 56.58 nM), dose-dependently promoting HepG2 cell death in a co-culture model of HepG2/hPD-L1 and Jurkat T cells, effectively inhibiting tumor growth (TGI of 76.4% at 90 mg/kg) in an immune checkpoint humanized mouse model with no obvious toxicity




Analytical data click for PDF file



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