Glixx Laboratories Inc
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Chemical Name: (S)-5-Hydroxy-3-(2-((((1-((1-methyl-1H-imidazol-4-yl)methyl)-1H-indol-6-yl)methyl)amino)methyl)-1H-indol-3-yl)isoindolin-1-one
Purity: >98% (HPLC)
Novel potent inhibitor for GTP-bound KRAS, binding to KRASG12D, inhibiting GTP-KRASG12D binding to effectors like SOS1, CRAF and PI3Kα, showing pERK(2h) modulation and antiproliferative effects in KRASmut cells (NCI-H358)
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