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Glixx Laboratorie
CAS: N/A
Chemical Name: Miro1 Reducer; N-(3-Fluorophenyl)-N'-(4-{[6-(1H-imidazol-1-yl)-4-pyrimidinyl]amino}phenyl)urea
Purity: >98% (HPLC)
Novel degrader of Miro1 (mitochondrial Rho GTPase 1), reducing Miro1 levels in fibroblasts and stress-induced degeneration of dopaminergic neurons derived from Parkinson's disease (PD) patients, as well as age-dependent neuronal loss and prolongs lifespan in fly PD model
References:
1) https://www.nature.com/articles/s42255-021-00443-2
2) https://www.cell.com/cell-metabolism/pdf/S1550-4131(19)30497-8.pdf
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