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CAS: 2621927-57-7
Chemical Name: 4-(4-((1R,5S)-3,8-Diazabicyclo[3.2.1]octan-3-yl)-8-fluoro-2-((tetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)pyrido[4,3-d]pyrimidin-7-yl)-5-ethynylnaphthalen-2-ol
For Lab R&D Uses Only
Purity: >98% (HPLC)
Novel KRAS(G12D) inhibitor, binding to both the GDP state and the GTP state of KRAS(G12D) in a cell-free system, engaging KRAS mutants and drives antiproliferation, demonstrating time- and dose-dependent inhibition of the KRAS(G12D):CRAF(RBD) interaction
Ref: https://www.nature.com/articles/s41589-022-00985-w
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