Glixx Laboratories Inc

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Glixx Laboratorie

 

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MRTX-EX185

 

CAS: N/A

 

Chemical Name: 4-(4-((1R,5S)-3,8-Diazabicyclo[3.2.1]octan-3-yl)-8-fluoro-2-((tetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)pyrido[4,3-d]pyrimidin-7-yl)-5-ethynylnaphthalen-2-ol

 

 
GLXC-25475For Lab R&D Uses Only
        Cat No: GLXC-25475

 

Purity:               >98% (HPLC)

Storage:             Refrigerator (4 °C)

 

 

Product Description:

Novel KRAS(G12D) inhibitor, binding to both the GDP state and the GTP state of KRAS(G12D) in a cell-free system, engaging KRAS mutants and drives antiproliferation, demonstrating time- and dose-dependent inhibition of the KRAS(G12D):CRAF(RBD) interaction

 

Ref: https://www.nature.com/articles/s41589-022-00985-w

 

Analytical data click for PDF file

 

 

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