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Glixx Laboratorie
CAS: 2793405-20-4
Chemical Name: 1-((S)-12-(((R)-1-(3-(Difluoromethyl)-2-fluorophenyl)ethyl)amino)-10-methyl-2,3,4,4a,5,6-hexahydro-1H-pyrazino[1',2':4,5][1,4]oxazepino[3,2-g]quinazoline-3-carbonyl)cyclopropane-1-carbonitrile
Purity: >98% (HPLC)
Novel potent orally bioavailable SOS1 inhibitor, strongly disrupting the protein-protein interaction between SOS1 and KRAS with low IC50 values of 3.9 nM (biochemical) and 21 nM (cellular)
Ref: https://pubs.acs.org/doi/10.1021/acs.jmedchem.2c00986
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