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CAS: N/A
Chemical Name: tert-Butyl (2'R,3R)-2'-(5-fluoro-4'-(methoxycarbonyl)-3'-(methylsulfonyl)-[1,1'-biphenyl]-3-yl)-2-oxospiro[indoline-3,3'-pyrrolidine]-1'-carboxylate
Purity: >98% (HPLC)
Novel potent LXRβ agonist, significantly inhibiting RANKL-induced osteoclast differentiation and bone resorption in vitro and in vivo, selectively activating LXRβ to promote intracellular cholesterol exclusion in osteoclasts and reducing extracellular cholesterol uptake and thereby inhibited osteoclast production
Reference:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.2c01661
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