Glixx Laboratories Inc
Your exclusive source for bioactive molecules
Chemical Name: N1-(2-Aminophenyl)-N4-((S)-1-(((R)-3-methyl-1-((3aR,4R,6S,7aS)-7a-methylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butyl)amino)-1-oxo-3-phenylpropan-2-yl)terephthalamide
Purity: >98% (HPLC)
Novel dual inhibitor of HDACs and proteasomes, exhibiting good antiproliferative activities on the MM cell lines RPMI-8226, U266, and KM3 (IC50 values of 6.66, 4.31, and 10.1 nM, respectively) and showing more potent antiproliferative activities against the bortezomib-resistant MM cell line KM3/BTZ compared with bortezomib (IC50 values of 8.98 vs. 226 nM, P < 0.01) and even better than the combination of the HDAC inhibitor MS-275 and bortezomib (1:1) (IC50 values of 8.98 vs. 98.0 nM, P < 0.01).
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