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CAS: N/A
Chemical Name: N-(3-(5-((4-(1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxapentadecan-15-oyl)cyclohexyl)(methyl)amino)-3-(pyrimidin-5-yl)-1H-pyrrolo[3,2-b]pyridin-1-yl)-2,4-difluorophenyl)propane-1-sulfonamide
Purity: >98% (HPLC)
PROTAC directed against BRAF mutant V600E, displaying superior specificity and inhibitory properties relative to non-PROTAC controls in BRAF(V600E) cell lines, harboring alternative BRAF mutations that impart resistance to conventional BRAF inhibitors
Ref: https://www.nature.com/articles/s41589-020-0609-7
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