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Glixx Laboratorie
CAS: 2415281-52-4
Chemical Name: N-(2-Amino-4-fluorophenyl)-4-(((4-((5-methyl-1H-pyrazol-3-yl)amino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)thio)methyl)benzamide
Purity: >98% (HPLC)
Novel potent CBP/p300-Snail interaction inhibitor, suppressing tumor growth and metastasis in wild-type p53-expressing cancer, forming a high-affinity interaction with the evolutionarily conserved arginine-174 pocket of Snail protein, reversing Snail-mediated epithelial-mesenchymal transition (EMT) and impairs EMT-associated tumor invasion and metastasis
Ref: https://advances.sciencemag.org/content/6/17/eaaw8500
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