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CAS: N/A
Chemical Name: NSC-828122; 3-(Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-(((2-morpholinoethyl)amino)methyl)-3-(trifluoromethyl)phenyl)benzamide
For Lab R&D Uses Only
Purity: >98% (HPLC)
Novel BRAF dimer kinase inhibitor, being selective for oncogenic BRAF dimers, showing high inhibitory potency IC50=10nM against BRAFV600E kinase activity, inducing an αC-IN* conformation within the BRAFV600E dimer through interactions within its allosteric site
Reference:
https://www.nature.com/articles/s41467-020-18123-2
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