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CAS: 1887095-82-0
Chemical Name: (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-(2-((1-(32-(4-amino-3-(2-aminobenzo[d]oxazol-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-27-oxo-3,6,9,12,15,18,21,24-octaoxa-28-azadotriacontyl)-1H-1,2,3-triazol-4-yl)methoxy)ethoxy)-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone
Purity: >98% (HPLC)
Novel dual mTORC1/2 inhibitor combined with Rapamycin and MLN0128, overcoming drug resistance, binding to FKBP12 results in targeted and durable inhibition of mTORC1/2
References:
1) https://www.nature.com/articles/s41589-020-0596
2) https://www.frontiersin.org/articles/10.3389/fonc.2020.01012/full
3) https://onlinelibrary.wiley.com/doi/full/10.1111/cas.14395
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