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CAS: 2412518-81-9
Chemical Name: trans-Phototrexate; (E)-(4-((2,4-Diaminoquinazolin-6-yl)diazenyl)benzoyl)-L-glutamic acid
Purity: >98% (HPLC)
Novel azo isostere of methotrexate (MTX), an inhibitor of E.coli dihydrofolate reductase (eDHFR ), inhibiting eDHFR controlled in a manner dependent on the light wavelength, with real-time reversible control of eDHFR activity
References:
https://pubs.acs.org/doi/10.1021/acschembio.2c00749
https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cbic.201800816
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