Glixx Laboratories Inc
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Glixx Laboratorie
CAS: 1391712-60-9 (free base)
Chemical Name: EGFR inhibitor L15; 2-[[5-Chloro-2-[[(6S)-6-[4-(2-hydroxyethyl)piperazin-1-yl]-1-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl]amino]pyrimidin-4-yl]amino]-N-methylbenzamide mono-hydrochloride
For Lab R&D Uses Only
Purity: >98% (HPLC)
Fourth-generation epidermal growth factor receptor (EGFR) inhibitor, demonstrating potent inhibitory activity against the L858R/T790M/C797S mutant EGFR (IC50 = 16.43 nM), exhibiting 5-fold selectivity over wild-type EGFR (IC50 = 80.96 nM)
Reference:
https://pubs.acs.org/doi/10.1021/acsmedchemlett.5c00194
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