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 ABL001

 

CAS: 1492952-76-7

 

Chemical Name: Asciminib; NVP-ABL001; N-[4-[Chloro(difluoro)methoxy]phenyl]-6-[(3R)-3-hydroxypyrrolidin-1-yl]-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide

 

 

GLXC-11157        Cat No: GLXC-11157

                  For Lab R&D Uses Only

 

Purity:               >98% (HPLC)

Storage:             Refrigerator (4 °C)

 


Product Description:

Allosteric kinase inhibitor, mimicing the autoinhibitory myristoyl group, activating the kinase by relieving physiologic autoinhibition, targeting the myristoyl pocket of the ABL1 kinase

 

References:

1) https://www.tandfonline.com/doi/full/10.1080/10428194.2020.1791856

2) https://bmccancer.biomedcentral.com/articles/10.1186/s12885-020-06782-9

3) https://www.nejm.org/doi/10.1056/NEJMc2000116?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed

 

Analytical data click for PDF file

 

 

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