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CAS: 2413716-15-9 (non-TFA salt)
Chemical Name: 4-(2-(5-((Diethylamino)methyl)-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-2-isopropylbenzoic acid TFA salt
Purity: >98% (HPLC)
Novel Inhibitor of the malaria parasite protein kinase CLK3, inhibiting the development of liver-stage parasites, killing asexual blood-stage parasites at the trophozoite and schizont stages of the erythrocytic cycle, blocking the development of sexual gametocytes that infect mosquitoes, and blocks exflagellation that results in male gametes
References:
1) https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c00451
2) https://science.sciencemag.org/content/365/6456/eaau1682/tab-figures-data
3) https://phys.org/news/2019-10-compound-malaria-parasite-lifecycle.html
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