Glixx Laboratories Inc
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Chemical Name: CA-4948; 2-(2-Methylpyridin-4-yl)-N-[2-morpholin-4-yl-5-[(3R)-3-oxidanylpyrrolidin-1-yl]-[1,3]oxazolo[4,5-b]pyridin-6-yl]-1,3-oxazole-4-carboxamide
Purity: >98% (HPLC)
Novel oral IRAK4 inhibitor for treatment of hematologic malignancies, demonstrating moderate to high selectivity in a panel of 329 kinases as well as exhibiting desirable ADME and PK profiles and showing >90% tumor growth inhibition in relevant tumor models with excellent correlation with in vivo PD modulation
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