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CAS: N/A
Chemical Name: (3R)-3-((2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-yl)amino)-N-(8-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)octyl)pyrrolidine-1-carboxamide
Purity: >98% (HPLC)
Novel PAK1-selective degrader, inducing selective degradation of PAK1 and displaying enhanced anti-proliferative effects relative to its parent compound in PAK1-dependent, but not PAK2-dependent, cell lines
Reference:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.2c00756
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