For Lab R&D Uses Only

Purity:               >98% (HPLC)

Product Description:

Novel inhibitor of TGF-β/Smad signaling, binding to Smad3 to impair N protein-induced Smad3 activation, downregulating N protein-induced α-SMA and COL1A1 expression levels and collagen secretion in a time- and dose-dependent manner in HFL-1 cells, effectively inhibiting TGF-β-induced Smad3 phosphorylation and α-SMA and COL1A1 expression in HFL-1 cells (human lung fibroblasts) as well as in AC16 (human cardiomyocytes), LX-2 (human hepatic stellate cells), and human primary dermal cells

Reference:

https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(23)00053-3

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