Glixx Laboratories Inc
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Glixx Laboratorie
CAS: N/A
Chemical Name: (Z)-3-(Carboxymethyl)-1,1-dimethyl-2-((3-methylbenzo[d]thiazol-2(3H)-ylidene)methyl)-1H-benzo[e]indol-3-ium bromide
For Lab R&D Uses Only
Purity: >98% (HPLC)
Novel G4-RNA-targeting ligand, showing strong affinity (Kd = 0.05-0.28 μM) for G4-RNAs, inhibiting KRAS and NRAS translation, disrupting PI3K/AKT and MAPK/ERK signaling, reactivating the DNA damage response, inducing S-phase arrest, and suppressing DNA replication and energy metabolism, leading to impaired migration and apoptosis in HCT-116 cells
Reference:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.5c03088
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