Glixx Laboratories Inc
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Glixx Laboratorie
CAS: 1903008-80-9
Chemical Name: Lazertinib; GNS-1480; N-[5-[[4-[4-[(Dimethylamino)methyl]-3-phenylpyrazol-1-yl]pyrimidin-2-yl]amino]-4-methoxy-2-morpholin-4-ylphenyl]prop-2-enamide
Purity: >98% (HPLC)
Novel irreversible EGFR-TKI with potent intracranial activity in EGFR mutant non-small cell lung cancer, showing more potent inhibition of cancer cell growth compared to osimertinib in cancer cells harboring EGFR mutations (L858R/T790 M) with IC50 of 2 nM vs 8 nM and GI50 of 3.6 nM vs 11.8 nM respectively
References:
1) https://clincancerres.aacrjournals.org/content/25/8/2575
2) https://www.e-crt.org/journal/view.php?doi=10.4143/crt.2020.278
3) https://www.sciencedirect.com/science/article/abs/pii/S0223523419311183?via%3Dihub
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