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Dex-Dox

 

CAS: N/A

 

Chemical Name: 2-((8S,9R,11S,13S,14S,16R,17R)-9-Fluoro-11,17-dihydroxy-13,16-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl 2-(4-(((2-(4-(((((2S,3S,4S,6R)-3-hydroxy-2-methyl-6-(((1S,3S)-3,5,12-trihydroxy-3-(2-hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl)oxy)tetrahydro-2H-pyran-4-yl)carbamoyl)oxy)methyl)phenoxy)-2-oxoethyl)thio)methyl)-1H-1,2,3-triazol-1-yl)acetate

 

 
GLXC-23947For Lab R&D Uses Only
        Cat No: GLXC-23947

 

Purity:               >98% (HPLC)

Storage:             Refrigerator (4 °C)

 

 

Product Description:

Novel reactive oxygen species (ROS)-responsive prodrug, being composed of the anti-inflammatory glucocorticoid dexamethasone (Dex) conjugated with antitumor doxorubicin (Dox), overcoming multidrug resistance (MDR) in tumor cells, promoting apoptosis and inhibiting angiogenesis in drug-resistant cells

 

Reference:

https://pubs.acs.org/doi/10.1021/acs.jmedchem.5c02565

 

Analytical data click for PDF file

 

 

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