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CAS: N/A
Chemical Name: (S)-2-Amino-4-((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(3-(3-carbamoylphenyl)prop-2-yn-1-yl)amino)butanoic acid
Purity: >98% (HPLC)
Novel tight-binding bisubstrate inhibitor for Nicotinamide N-Methyltransferase (NNMT), showing interaction with both the substrate and cofactor binding sites on NNMT, demonstrating a Ki value of 1.6±0.3 nM, which is the most potent inhibitor to date
Ref: https://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.9b01255
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