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CAS: N/A
Chemical Name: USP7-IN-X36; 6-((1-(2-Chloro-4-(furan-2-yl)benzyl)-4-hydroxypiperidin-4-yl)methyl)-3-(4-fluorophenyl)-2-methyl-2,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
Purity: >98% (HPLC)
Novel USP7 inhibitor with good oral PK profiles (rat: F = 40.8% and T1/2 = 3.5 h), exhibiting significant antitumor efficacy in the MC38 colon cancer syngeneic mouse model, at least partly through upregulating the tumor infiltration of CD8+ T, NK, and NKT cells and downregulating that of Tregs and MDSCs
Reference:
https://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.2c01444
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