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CAS: N/A
Chemical Name: 2-(5-(Cyclopropylmethyl)-3-(3-(6-(13-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-13-oxotridecanamido)hex-1-yn-1-yl)phenyl)-4-(4-sulfamoylbenzyl)-1H-pyrazol-1-yl)thiazole-4-carboxylic acid
Purity: >98% (HPLC)
The first LDH proteolysis targeting chimera (PROTAC) degrader, degrading both LDHA and LDHB significantly, suppressing the growth of both quasi-mesenchymal state and epithelial state pancreatic cancer cell lines
References:
https://pubmed.ncbi.nlm.nih.gov/?term=MS6105&sort=date
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